Detalhe da pesquisa
1.
Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.
Cell
; 168(1-2): 59-72.e13, 2017 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28065413
2.
Specialized interferon action in COVID-19.
Proc Natl Acad Sci U S A
; 119(11)2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35217532
3.
Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity.
Proc Natl Acad Sci U S A
; 116(48): 24231-24241, 2019 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699819
4.
Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.
Genome Res
; 27(10): 1645-1657, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28904012
5.
A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs.
Mol Cell
; 34(3): 322-32, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19450530
6.
Inhibition of telomerase recruitment and cancer cell death.
J Biol Chem
; 288(46): 33171-80, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24097987
7.
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
Nat Chem Biol
; 8(7): 646-54, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22660439
8.
The p53 circuit board.
Biochim Biophys Acta
; 1825(2): 229-44, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22333261
9.
FAM193A is a positive regulator of p53 activity.
Cell Rep
; 42(3): 112230, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36897777
10.
Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway.
Cancer Res
; 83(15): 2543-2556, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37205634
11.
Down syndrome is associated with altered frequency and functioning of tracheal multiciliated cells, and response to influenza virus infection.
iScience
; 26(8): 107361, 2023 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37554445
12.
Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development.
Elife
; 122023 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36656118
13.
Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition.
Sci Adv
; 9(26): eadg6218, 2023 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37379383
14.
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Nat Metab
; 5(12): 2131-2147, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37957387
15.
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model.
Nat Genet
; 55(6): 1034-1047, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37277650
16.
PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response.
Nat Commun
; 13(1): 7400, 2022 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36456590
17.
A novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy.
Neuro Oncol
; 24(3): 414-426, 2022 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34477871
18.
IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome.
Cell Rep
; 41(13): 111883, 2022 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36577365
19.
Knockdown of SLBP results in nuclear retention of histone mRNA.
RNA
; 15(3): 459-72, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19155325
20.
Global Analyses to Identify Direct Transcriptional Targets of p53.
Methods Mol Biol
; 2267: 19-56, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33786783